{"id":3011,"date":"2024-09-18T14:18:55","date_gmt":"2024-09-18T14:18:55","guid":{"rendered":"https:\/\/emb.eurospital.com\/?post_type=diagnostic_tests&p=3011"},"modified":"2024-10-11T09:09:23","modified_gmt":"2024-10-11T09:09:23","slug":"eu-gen-mthfr-dual-type","status":"publish","type":"diagnostic_tests","link":"https:\/\/emb.eurospital.com\/en\/diagnostic-tests\/eu-gen-mthfr-dual-type\/","title":{"rendered":"Eu-Gen MTHFR Dual-Type"},"content":{"rendered":"\n

Plasma homocysteine \u200b\u200blevels are associated with an increased risk of venous thromboembolism and cardiovascular diseases, which, in the European population, have a prevalence of approximately 1-2 people per 1000\/year. These are multifactorial diseases, therefore caused by both environmental factors and a genetic predisposition.
Today, among the most characterized genetic markers that predispose to the condition of thrombophilia is the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR) that catalyzes the re-methylation of homocysteine \u200b\u200binto methionine. In particular, the C677T and A1298C polymorphisms of the MTHFR gene represent the most common genetic predisposition factors.<\/p>\n\n\n\n

In fact, subjects carrying these variants have a deficit in the functionality of the MTHFR enzyme and a consequent increase in blood levels of homocysteine \u200b\u200bthat has been shown to be linked to a greater risk of incurring cardiovascular diseases.<\/p>\n\n\n\n

Eu-Gen MTHFR Dual Type is a qualitative kit in Multiplex Real Time PCR that offers a combined diagnostic solution to determine the genotype of both polymorphisms affecting the MTHFR gene.<\/p>\n\n\n\n

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